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Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure
There are a few studies looking at response in women with PCOS, and one in women with unexplained infertility neither necessarily strongly related to women with or recovered from hypothalamic amenorrhea
Bariatric surgery has decades of long-term research showing sustained weight loss, while the long-term effects of GLP-1 medications are still being studied.
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Ahren B, Hirsch IB, Pieber TR et al (2016) Efficacy and safety of liraglutide added to capped insulin treatment in subjects with type 1 diabetes: the adjunct two randomized trial
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