Study shows that treatment with GSK864 as IDH1 inhibitor binding an allosteric site on IDH1 reduces the NADPH/NADP + ratio and prolongs the survival of glioblastoma multiforme (GBM) PDXs model
Elizondo-Luvano JH, Rodrguez-Garza NE, Bazalda-Rodrguez AF, Romo-Senz CI, Tamez-Guerra P, Verde-Star MJ, Gomez-Flores R, Quintanilla-Licea R (2023) Cytotoxic, anti-hemolytic, and antioxidant activities of Ruta chalepensis L
TB-500 bioavailability follows similar patterns, though its larger molecular size may result in slightly lower nasal absorption compared to BPC-157
The study confirmed the physical interaction between MIA3 and CHAC1 through coimmunoprecipitation and confocal microscopy, highlighting the MIA3/CHAC1/GSH axis as a key mechanism driving HCC progression and a potential target for therapeutic intervention (Wanbiao et al., 2023)
& Tuveson, D