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Lilly's triple agonist, retatrutide, demonstrated significant reductions in A1C and weight in first Phase 3 trial for treatment of type 2 diabetes For the primary endpoint, retatrutide lowered A1C by an average of 1.7% to 2.0% across doses at 40 weeks in TRANSCEND-T2D-1 Participants taking retatrutide 12 mg lost an average of 36.6 lbs (16.8%) No weight loss plateau was observed with retatrutide, with participants continuing their weight loss trajectory through 40 weeks 1,2 For the primary endpoint, participants taking retatrutide achieved average A1C reductions of up to 2.0%, using the efficacy estimand

I used to have to take a nap after school, says Frankie, now 17

What we saw were really great, clinically significant reductions of liver fat, even over that short period of time, Lake said

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Our findings make sense from a theoretical standpoint, since GLP-1 medications do have an anti-inflammatory mechanism, but we cant guarantee the association with uveitis. More research with different methodologies, such as retrospective chart reviews and prospective trials, is needed to confirm the findings and inform clinical practice