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Constipation is often rooted in gut motility issues, as well as nutrient deficiencies ( magnesium deficiency is a very common one, especially for those with Hashimotos)
The downstream targets of Nrf2, including SLC7A11 and heme oxygenase 1 (HO-1), have been implicated in intracellular iron metabolism and GPX4 synthesis, both of which are essential in ferroptosis regulation (Zhang et al., 2022)
Its therefore best to avoid taking magnesium and calcium supplements at the same time
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