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These miRNAs reside in intronic regions within SREBP-1 and 2, the key transcriptional regulators of lipid metabolism 87 , and control the expression of carnitine O -octanoyltransferase (CROT), CPT1A, hydroxyacyl coenzyme A (hydroxyacyl-CoA) dehydrogenase subunit beta (HADHB), and AMPK, targeting their 3 UTR 88

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Common side effects may include temporary swelling or bruising at the injection site

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Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study