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Systemic supplementation typically begins with low doses and the minimum effective amount

GLP-1 receptors are found in several brain regions, including: The ventral tegmental area (VTA) The nucleus accumbens The prefrontal cortex When activated by GLP-1, these receptors appear to reduce the release of dopamine in response to addictive substances

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The most common adverse reactions were nausea, diarrhea, constipation, and vomiting, and the treatment discontinuation rate due to adverse reactions was 11.3% in the 12mg group and 6.9% in the 9mg group, which was higher than the placebo group (4.9%)