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Using the so-called LeiCNS-PK3.0 physiologically-based pharmacokinetic (#PBPK) model and 34 common P-gp inhibitors, the authors simulated scenarios with and without inhibition

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Among these potential key players, Roche continues to stand out with multiple obesity candidates within its pipeline, all in phase II trials (as of November 2025), and it is expected to enter the market in 2029 or later

In addition to the canonical role in gas exchange or maintenance of acid-base balance, accumulating evidence indicates that erythrocytes are involved in the regulation of blood flow, hemostasis, redox equilibrium, and immune response

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