Functional morphology of the bloodbrain barrier in health and disease
In this work, the authors witnessed the high BBB permeability of these nanoformulations, thanks to the B6 peptide that acts via lipid raft-mediated and clathrin-mediated endocytosis (Liu et al., 2013a), and their ability to inhibit A aggregation and disaggregate preformed A fibrils (Yin et al., 2015)
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Preclinical achievements of polymeric nanoparticles-mediated drug delivery in Alzheimers disease Most of the current conventional therapeutics used in the treatment of neurodegenerative disorders, including AD, are based on high molecular weight (Mw 500 Da) Abs, peptides and proteins, which are unable to go through the BBB by themselves (Mukherjee et al., 2020)
Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial