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This has also been suggested by a guideline of the Italian Society for the Study of Diabetes and the Italian Endocrinological Society (29) and fluid retention which would add to the ones of hypercortisolism metformin either as monotherapy or, if glycemic targets cannot be reached, in combination with other oral antidiabetic drugs, GLP-1 receptor agonists or insulin should be considered as first choice

Lancet 394 , 21842196 (2019)

This mechanism has prompted clinical curiosity about whether exogenous GLP-1 agonists could support metabolic stability during perimenopause, though robust perimenopause-specific trials remain limited

GHK-Cu is een fascinerende koperbindende tripeptide bestaande uit slechts 3 aminozuren (glycyl-L-histidyl-L-lysine), gekoppeld aan een koperion (Cu)

Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential