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In DR, CFL2 has been proven to be overexpressed in RPE cells induced by high glucose, and its upregulation exacerbates high glucose-induced cell ferroptosis (193)

428,429,430 The unconventional protein secretion pathway requires Golgi reassembly stacking protein (GRASP) and vesicular components linked to secretory autophagy, a nondegradative autophagic process promoting the trafficking of cargo to the plasma membrane

It is important to note, however, that the adaptive capacity of humans and some animals (penguins, bears, seals) to starvation differs, as these animals can survive for months without food or water

Some researchers have found certain types of mutation more often in patients with symptoms, whereas others have found different types of mutation in mothers without symptoms whose babies were identified as having PCD through newborn screening tests

doi:10.1016/j.lfs.2011.08.012 155