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It has also been associated with psychogeriatric dis-ease, depression, high neurotoxin activity, and a decrease in intellectual function such as episodic and visuospatial memory, attention, and abstract reasoning (20).Reynolds and colleagues found that 17 out of 24 hospitalized patients (71%) presenting severe folic acid deficiency were diagnosed with depression (46)

Subsequently, for these data as well as the alpha diversity analyses, each treatment group (within each phylum or genus for the relative abundance data) was analyzed for normal distribution (ShapiroWilk test) and the data across groups were tested for homoscedasticity (BrownForsythe test)