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The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated proteins, is up-regulated by various stressors

In addition to the direct effects of TRP depletion and KYN accumulation on immune cells, cancer cells also engage in metabolic competition with immune cells

The ensuing mechanistic study revealed that ebselen protected cells and mice models by lowering radiation-induced ROS production, followed by inhibition of lipid peroxidation, protein carbonylation, DNA damage, and ultimately apoptosis

82174163), and the Natural Science Foundation of Shandong Province (No