glp 1 receptor brain Interaction between GLP-1 signaling and neural reward pathways. GLP-1 Impaired brain glucose metabolism in

doi: 10.3969/j.issn.1674-8115.2011.10.029 271 TaoufikY.de Gor de HerveM.-G.CorgnacS.DurrbachA.Mami-ChouaibF

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Microbiota-derived metabolites represent a plausible mechanistic interface: SCFAs and secondary bile acids can strengthen epithelial barrier function, modulate host metabolism via FXR- and TGR5-dependent signaling, and attenuate low-grade inflammation, potentially reinforcing pharmacologically targeted pathways