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This indicates that its proliferative and cytoprotective effects on the gut epithelium are mediated indirectly via paracrine signaling ( GLP-2 is recognized as a key intestinal growth factor capable of enhancing mucosal proliferation, improving nutrient absorption, and maintaining gut barrier integrity ( Dipeptidyl peptidase IV DPP-IV, also known as CD26, is a serine protease that degrades both GLP-1 and GLP-2

2020;12(5):e8041

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Step 2 FDA Review of Recommendations: The FDA considers the panel's conclusions alongside internal review