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Escalating before steady state means escalating before you have seen the full effect of your current dose, which risks side effects from a drug level that is still rising

Protection of the BBB, the inhibition of the elements of the brain microvascular damage such as impairment of tight junctions, increased vesicular transcytosis, production of various cytokines, chemokines and reactive oxygen species offers novel therapeutic targets [11]

Receptors are proteins that sit in the membrane of cells and bind a specific molecule

Doctors can help decide which option fits a patients needs best

IGV-001 is created by treating a patients surgically resected glioblastoma tissue ex vivo with an antisense oligonucleotide and placing it into biodiffusion chambers, which are briefly implanted before standard radiotherapy and chemotherapy