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MDM2 inhibitors Nutlins, which were identified by screening a synthetic chemical library, were the first compounds reported to inhibit the interaction between MDM2 and p53

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The most studied cytokine known to cause barrier dysfunction is TNF-

While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)

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