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In DN cells, the use of Fer-1 is beneficial because it increases the expression of antioxidative genes to maintain redox homeostasis and alleviate ferroptosis [228]
Fig.3 Proportion of patients achieving MASH resolution without worsening of fibrosis with tirzepatide [6] While GLP-1 RAs are proving effective in treating MASH, their lack of direct action on liver tissue could limit their effectiveness in patients with advanced liver fibrosis or cirrhosis
However, the process of making energy also creates waste products
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