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The changes are mostly internal

Treatment of GLP-1-associated nausea typically starts with dietary modification, including eating smaller portions of food, eating smaller more frequent meals, avoiding foods high in fiber and fat, and increasing fluid intake with meals [7]

Pharmacokinetic study Plasma agonist concentration after a single IP injection (24 nmol kg 1 ) was measured with an exendin-4 C-terminus-specific ELISA (Phoenix Pharmaceuticals), a peptide region that does not differ between agonists, hence equally detecting exendin-4 and exendin-phe1 (confirmed by analysis of known concentrations of each agonist)

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