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"Effects of bedtime administration of zolpidem on sleep/wake cycle in healthy elderly volunteers." Journal of Clinical Pharmacology 35.11 (1995): 1092-1097

For people with existing heart disease or risk factors, caution is important while researchers continue to untangle how cannabis may affect cardiovascular health

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The addition of an SGLT-2 inhibitor to existing GLP-1 receptor agonist use was also associated with a reduced risk of cardiovascular mortality and heart failure compared with GLP-1 receptor agonists alone

To summarize the key results, the most prominent influence of cannabis was on insulin, followed by GLP-1 and total ghrelin, as further discussed below