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doi:10.1016/j.cell.2019.04.044

The development of GLP1R agonists primarily addresses the issue of the short half-life of natural GLP-1

Lovegrove, M

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The potential benefits of tirzepatide may include the following: Significant and sustained weight loss Tirzepatide is a dual GLP-1/GIP receptor agonist that helps significantly reduce body weight by enhancing insulin secretion, lowering glucagon levels, and delaying gastric emptying, which contribute to reduced calorie intake and weight loss