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Sancho-Vaello E, Gil-Carton D, Francois P, Bonetti EJ, Kreir M, Pothula KR

One case-control study reported that selenium-responsive glutathione peroxidase 1 (GPx1) activity was significantly lower in Keshan patients compared to healthy individuals

100+ studies on gene expression modulation, ECM remodeling, antioxidant pathways

Overall, these findings suggest a DsbA-dependent effect of monothiols, accelerating thiol oxidation in the periplasm, even though we did not observe direct interaction of oxidized glutathione with DsbA itself

Researchers study this compound to understand how blocking NNMT activity affects related metabolic pathways at the cellular level