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Even when GLP-1 analogs or modified forms of GLP-1 can escape DPP-4 attack, they remain prone to renal elimination given GLP-1's small molecular size (~3.4 kDa) [13], providing a second means by which GLP-1's plasma half-life is limited
These usually occur as the body adjusts to the medication
However, not for people with certain thyroid conditions and kidney disease
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