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Higher doses or irregular administration may increase the likelihood of nausea and upset stomach

GLP-1 receptor agonists are medications that mimic this hormone, amplifying its effects to produce meaningful, sustained weight loss

But the thigh typically offers a slightly larger usable fat zone compared to the back of the arm for most body types

Septerna has developed a native complex platform that can reconstitute the GLP-1 receptor within an artificial lipid bilayer, complexed with combinations of drug and internal cell signalling molecules, which replicates the dynamics of the signalling process at scale

It is, however, contraindicated for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)