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Structurally, the c-MET receptor is composed of a Semaphorin (SEMA) domain, a plexin-semaphorin-integrin (PSI) domain, and four consecutive immunoglobulin-plexin-transcription factors (IPT1-4) domains in the extracellular region, a single transmembrane helix (TM), and an intracellular KD (Fig

The authors graded the human evidence at the two lowest tiers science recognizes, and noted that no clinical safety data exist at all

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