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Glucagon receptor activation in the liver stimulates glycogenolysis and gluconeogenesis, but more relevantly for metabolic research, it also activates brown adipose tissue thermogenesis and increases fatty acid oxidation in hepatocytes
The primary outcome is the percentage of participants with absence of NASH with no worsening of fibrosis on liver histology [64]
Convenient once-weekly dosing structure for consistent weekly tracking
HFD, high-fat diet
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