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This two-step injection protocol is known to induce OA-like cartilage degeneration, particularly in the lateral portion of the femoral condyle

Safety and discontinuation rates are comparable to other GLP-1 drugs

Phase 2 trial - New England Journal of Medicine, 2023 Average drop in liver fat in the highest-dose group after 24 weeks in a smaller fatty-liver sub-study, measured against each person's starting level

Vitamin B12 There is four types of parenteral Vitamin B12 available: Cyanocobalamin 100 mcg/ml and 1000 mcg/ml best used as IM to prevent rapid loss via kidneys Hydroxycobalamin IM (compounded 1000 mcg/ml or more) known as long acting B12 (binds better to plasma proteins than cyanocobalamin) Methylcobalamin IV (compounded 1000 mcg or more up to 5000 mcg/ml) Adenosylcobalamin IV Common dose is 1000 mcg IM or IV Vitamin B12 as hydroxycobalamin is synthesized exclusively by microorganisms and is found in the liver of animals bound to protein as methylcobalamin = metabolically active form of Vitamin B12 Hydroxycobalamin is a chelator of cyanide and is used in cyanide poisoning Hydroxocobalamin is most generally used for vitamin B12 replacement therapy and is considered the drug of choice for vitamin B12 deficiency by the Martindale Extra Pharmacopoeia (Sweetman, 2002) and the World Health Organization (WHO) Model List of Essential Drugs

Competitive athletes should be aware of WADAs S0 prohibition on non-approved substances