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doi: 10.1158/15357163.MCT-20-0271 51 RecouvreuxMVMoldenhauerMRGalenkampKMOJungMJamesBZhangYet al
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GLP1s are disrupting adjacent therapeutic markets
An ongoing phase Ib trial (NCT04167540) is designed to evaluate the safety and potential clinical effect of MRI-guided intraputaminal delivery of AAV2-GDNF in two cohorts of patients with either early-stage or advanced PD, thus contributing with important knowledge on the therapeutic effect early in PD course
It is central to: Detoxification: Neutralizing free radicals and heavy metals Immune defense: Maintaining lymphocyte and macrophage function Redox homeostasis: Regulating disulfide bonds and antioxidant recycling Cellular repair: Protecting lipid membranes and mitochondrial DNA Despite its significance, traditional glutathione supplements face major limitations: Poor intestinal absorption Rapid breakdown into constituent amino acids Minimal rise in systemic glutathione levels Weak clinical outcomes This gap between glutathiones potential and its real-world efficacy is what motivated the move toward liposomal delivery systems
