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Patients may choose one or the other, but may find that combination of the two is most effective

(2025) 8:e70045

The efficacy of systemic GLP-1R agonists to attenuate cocaine seeking is associated with increased activity of GABA neurons in the VTA While an emerging literature indicates that activation of VTA GLP-1Rs is sufficient to reduce drug-seeking behavior 8,14 , the cell type-specific neural mechanisms underlying the efficacy of GLP-1R agonists and increased GLP-1 signaling in the VTA on cocaine seeking remain largely unknown

Individuals on certain medications Some drugs may interact with antioxidant therapies

Lancet 2019;393:1937-47.PubMed 21