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J Steroid Biochem 1987;27(4-6):11351144

All current evidence comes from preclinical animal and cellular studies, meaning its efficacy and safety in people remain unproven

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[59] Approval of the original brand-name versions (such as Ozempic) was based on a biologic (recombinant DNA) production process using a genetically-modified yeast ( Saccharomyces cerevisiae ) to produce a precursor to semaglutide, and subsequent chemical processes (protein purification) to create the active ingredient