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Peer review Peer review information Nature Metabolism thanks the anonymous reviewer(s) for their contribution to the peer review of this work

This decline doesnt happen all at once, but slowly, often unnoticed at first

The PKA inhibitor 8-Br-Rp-cAMPS (Rp-cAMPS) was purchased from BioLog Life Science Institute (Bremen, Germany), the SSTR2 antagonist CYN154806 from Tocris Bioscience (Bristol, UK), the Gpr119 agonist AS1269574 from Tocris and pertussis toxin from Sigma