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4.1 Inflammation and endothelial dysfunction Chronic systemic inflammation is a hallmark of many immune-mediated skin diseases and is considered the main driving factor of endothelial dysfunction (50, 51), while endothelial dysfunction underlies the pathophysiology of ED (52, 53)

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Liposomes also show a strong affinity for keratin in the stratum corneum, promoting deeper skin infiltration, higher absorption, and better drug retention, and they have been utilized as local anesthetics [11]

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