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10.1016/j.amjhyper.2005.02.012 219 MalaisseW.Malaisse-LegaeF

= 1.5) in the placebo group ( n = 4)

Together, these approaches might provide additive benefits for weight reduction and metabolic health

Circadian pathway Modulation of the circadian rhythm Regulates sleep-wake cycles Normalizes sleep disorders Effects lasting several days Opioid route Endogenous opioid system Pain perception module Blocked by naloxone Supports weaning management Stress response Hypothalamic-pituitary-adrenal axis Reduces stress responses Reduces cortisol secretion Improves stress management Unique biological properties Unlike most peptides, DSIP freely crosses the blood-brain barrier and can be absorbed by the intestine without enzymatic degradation