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A 2026 analysis in the Journal of Medical Internet Research found real-world discontinuation rates far exceed clinical trial numbers, with up to 70% of patients stopping treatment within 24 months -- often because of these effects

However, more studies are needed to understand their effects.

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Microglia play important roles in the immune regulation in the brain, monitoring CNS and inflammatory factors, and clearing A and cell debris (Sarlus and Heneka, 2017)

Weight loss velocity peaks during weeks 12 through 24, averaging approximately 1.8 pounds per week during this window