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Weight Gain After Stopping GLP-1: Appetite, Hunger, and Metabolic Changes While GLP-1 medications can drive substantial weight loss during use, it isnt unusual for some of that weight to return after stopping

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Natural human GLP-1 exists primarily as GLP-1(7-36) amide, a peptide that is rapidly degraded by DPP-4, resulting in a half-life of only 2 to 3 minutes

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