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A disrupted redox balance, particularly elevated oxidized glutathione (GSSG), is implicated in brain aging and neurodegeneration

Circulating immune cells also serve as a critical link between vascular dysfunction, vascular inflammation, and the systemic immune response ( The glymphatic system The glymphatic system is a brain-wide network of lymphatic vessels that line the dural sinuses

Clinical decisions should therefore remain individualized, and continued long-term surveillance is warranted

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