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Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]

The combination of HRT, GLP-1 medications, adequate protein, and resistance training creates the optimal conditions for body recomposition

Packer, L., Witt, E

Increased blue staining indicated senescent cells [1]