discontinuing glp-1 ISPOR 2025: Exploring reasons for discontinuation Researchers and the public alike

Many people regain weight when they stop taking them, which is why patients should think carefully about whether they are ready for long-term treatment, at least until we have better evidence on how to maintain weight loss after stopping medication or treatments that more durably change the course of obesity

doi: 10.1186/1742-2094-11-8 164 ChenYLiDSunLQiKShiL

Both medications accumulate to steady state within 3-4 weeks of consistent weekly injections, though tirzepatide's slightly shorter half-life means it clears more rapidly if doses are delayed

It all comes down to managing enzymatic activity and oxidation, which accelerate exponentially at higher temperatures

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