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The second problem is that reference ranges are quite broad and based on the current, generally healthy population, not an optimally healthy population
Temperature-related complaints like chills and hot flashes appeared consistently enough in real-world reports to be notable, but the study does not establish that these symptoms are caused by the medications
Toxic Dose The toxic dose of acetaminophen can vary widely in individual patients, but is somewhere between 7.5 and 15 grams in most adults (6,7)
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