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Lysosomes play a pivotal role in integrating nutrient and energy signals, with mTORC1 responding to amino acids through the Ragulator-Rag GTPase complex and AMPK sensing glucose deficiency and energy stress through the AXIN-LKB1 complex [295, 296]
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Mitochondria: A therapeutic target in acute kidney injury
The activity of SIRT1 also modulates the formation of H3K9me3, H4K20me3 and H3K79me2 to regulate chromatin
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