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This outcome reflects both the inherent difficulty of treating Alzheimer's disease and questions about whether a single neuroprotective mechanism, without addressing amyloid and tau pathology more directly, can be sufficient

A semi-logarithmic plot of the fraction of noninhibited enzyme activity ln( v i / v 0 ) versus incubation time yielded linear curves with increasing slopes, equivalent to the apparent rate constant of irreversible inhibition ( k obs ) in GR (Figure 4A) and in TrxR (Figure 4C) assays

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