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Reverse research inducing cirrhosis in mice showed that cirrhosis leads to dysfunction of the intestinal barrier, and found that FXR agonists can ameliorate the translocation of gut bacteria to the liver by restoring the integrity of the gut-vascular barrier (Sorribas et al., 2019)
Most practitioners recommend stopping the previous medication and starting the new one at the lowest dose with standard titration
121 National Center for Biotechnology Information (2023e)
The SURMOUNT clinical trials demonstrated that tirzepatide-treated participants achieved weight reductions of 2022% over 68 weeks, compared to 16% for semaglutide alone
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