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Previous reports indicate, that sea urchins in general, have a high cysteine content, which serves various important roles including: (1) reinforcing intermolecular disulphide bonds, for maintaining protein structure 55 , (2) binding sites for heavy metals, supporting detoxification processes 56 , (3) regulating osmotic pressure by enhancing taurine synthesis 27 and (4) maintaining the redox state and supports antioxidant functions 57,58,59

In the following section, we translate these mechanistic findings into clinical applications, evaluating emerging strategiesincluding ferroptosis inhibitors, iron chelation therapies, and biomarker-driven approachesdesigned to disrupt this pathological cycle and modify the progression of COPD

doi: 10.1016/j.bbadis.2014.05.031 67 MyhillSBoothNEMcLaren-HowardJ

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