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518,519,520,521 Hepatocellular carcinoma (HCC) Initially developed for treating diabetes, GLP-1RAs have shown potential in treating NASH, which is closely related to HCC
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Finally, tirzepatide, retatrutide and the triple agonist HM15211 (efocipegtrutide) have shown a strong anti-inflammatory and anti-fibrotic effect in the liver during metabolic dysfunction associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis [88]
These results provide a structural framework for understanding class B GPCR activation through hormone binding
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