Microplastics exert multidimensional effects on the nervous system at the molecular level [e.g., microplastic exposure interferes with the ROS/TGF- /Akt/FoxO3a signaling pathway (4)], cellular level [microplastics disrupt tight junctions between endothelial cells and enter endothelial cells via endocytosis (5)], and organ level [e.g., in the hippocampus, exposure to nanopolystyrene induces P53-mediated ferritinophagy and ferroptosis in the rat hippocampus (6)]
Research shows that losing just 10% of body weight can significantly reduce osteoarthritis pain and improve physical function
Preclinical interaction studies typically cost $15,000$40,000 per compound pair, depending on the complexity of pharmacokinetic assays, CSF penetration analysis, and behavioral monitoring required
10.1038/cr.2017.155 101 PrietoK.CaoY.MohamedE.Trillo-TinocoJ.SierraR
Weight loss from semaglutide can improve testosterone levels and erectile function in men with obesity
