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Through various pathways, SIN suppresses the M1 polarization in macrophages, leading to a decrease in the production and secretion of diverse chemokines and pro-inflammatory cytokines, including TNF- and IL-8 (89, 104)

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GHK-Cu (glycyl-l-histidyl-l-lysine-copper), also called copper tri-peptide, is a naturally occurring copper-binding peptide found in human plasma, saliva, and urine

10.1016/j.molstruc.2013.01.049 37 GaoT

While metformin itself does not significantly increase UTI risk, it can cause GI side effects (especially diarrhea) that compound the dehydration problem