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Patients were followed up from the index date until death, loss to follow-up, development of a clinical outcome of interest, or the end of 2016, whichever came first, as the intention-to-treated (ITT) analysis scenario

Under physiological conditions, it is either remethylated to methionine or irreversibly metabolised through the transsulphuration pathway

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The primary risk is compounded stomach slowness leading to bloating, nausea, or acid reflux

For lyophilized powder, assume 48 hours at room temperature (acceptable risk)