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Interactions Some medications and other substances can interact with Contrave, including: Alcohol MAOIs (like isocarboxazid, linezolid, phenelzine, selegiline, or tranylcypromine) Drugs that increase dopamine levels in your system (like levodopa and amantadine) Drugs that affect the central nervous system (like antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medication) Drugs for depression or anxiety Antipsychotics Theophylline Systemic corticosteroids Prescription pain medicine or narcotics Medicine for attention deficit and hyperactivity disorder (ADHD) Medicine for seizures or barbiturates Muscle relaxants Anesthetics, including some dental anesthetics Dextromethorphan Diarrhea medication (such as diphenoxylate) Disulfiram Opioid pain or cough relievers (such as codeine and hydrocodone) Thioridazine Avoid drinking alcohol while taking Contrave

Gut microbes produce or metabolize a spectrum of bioactive compounds, including SCFAs, bile acids, and tryptophan derivatives, which collectively influence energy homeostasis, insulin sensitivity, and sex hormone balance