Antinociceptive and Analgesic Effects DSIP demonstrated a potent antinociceptive effect when administered intracerebroventricularly or intracisternally in rodent models establishing central analgesic activity independent of peripheral opioid mechanisms
Danuglipron lost out on both efficacy and safety, so its discontinuation was not unexpected
Rapid weight loss (or reduced fat mass) can also impact lean mass, bone density, skin/tissue quality, and facial appearance (sometimes noted as hollowing in the face)
doi: 10.1016/j.peptides.2013.07.015, 163 ZhengZ.ZongY.MaY.TianY.PangY.ZhangC.et al
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