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The latter is a competitor of 2-Oxoglutarate-dependent dioxygenases such as Ten-eleven translocation methylcytosine dioxygenase and therefore induces DNA hydroxymethylation and gene upregulation 52

Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease

doi: 10.1136/bmj.g2366 59 WentenMGaeblerJAHusseinMPelletierEMSmithDBGirasePet al

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The risks of microdosing are significant and multifaceted: Therapeutic inefficacy : Sub-therapeutic doses may fail to achieve meaningful improvements in glycaemic control or weight management, potentially delaying appropriate treatment and allowing disease progression