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Some evidence suggests that the two systems together affect both pleasure-driven eating and energy-driven hunger, which is part of why the CagriSema combination has shown such strong results in trials

Another angle is postoperative exercise or mobilization early mobilization might stimulate mitochondrial turnover and function, aiding recovery (though too-early mobilization if patient is unstable could be harmful, so balance needed)

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Do not use with Wilson's disease or active hepatic copper overload, and use caution with pregnancy, breastfeeding, or copper sensitivity